About the eXalt2 Study

The eXalt2 clinical study is for adults with ALK+ lung cancer who have previously received crizotinib or alectinib to treat their disease.

With this study we aim to evaluate the safety of ensartinib and see how tumors of previously treated patients respond to this medication.

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Who can participate?

You may be eligible to join the eXalt2 clinical study if you:

  • Are 18 years of age or older
  • Have been diagnosed with ALK+ lung cancer
  • Have received crizotinib or alectinib in the past


About 140 people with advanced cancer will participate in the eXalt2 clinical research study. Click on the map below to see if there is a study site located near you. Additional study sites may open in the future.

Xcovery USA map

About Ensartinib

Some genes can change and affect the way that tumors develop and grow. One example is the gene for anaplastic lymphoma kinase (ALK). Ensartinib, which is being tested in the eXalt2 study, acts specifically on tumors that have an altered ALK gene (ALK+ tumors). Xcovery’s previous research has theorized that ensartinib has the potential to block the effects of ALK. Moreover, preclinical research suggests that ensartinib can block ALK more strongly than other available cancer treatments.

What Happens During the Study?

If you are eligible and agree to participate in the eXalt2 clinical study, you will be required to:

  • Visit the study site as required by the study staff
  • Undergo study-related tests and procedures
  • Take ensartinib according to the instructions